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Your Position: Home > Integrin alpha D beta 2

Integrin alpha D beta 2

Brief Information

Name:Integrin alpha-4
Target Synonym:CD49D,Integrin alpha-IV,ITGA4,Integrin Subunit Alpha 4,Alpha 4 Subunit Of VLA-4 Receptor,VLA-4 Subunit Alpha,Integrin, Alpha 4 (Antigen CD49D, Alpha 4 Subunit Of VLA-4 Receptor),CD49 antigen-like family member D,Very Late Activation Protein 4 Receptor, Alpha 4 Subunit,Antigen CD49D, Alpha-4 Subunit Of VLA-4 Receptor,Integrin Alpha-4,269C Wild Type,CD49d Antigen,Antigen CD49D,IA4,Integrin alpha4
Number of Launched Drugs:1
Number of Drugs in Clinical Trials:3
Lastest Research Phase:Approved

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Cat. No. Species Product Description Structure Purity Feature
IT2-H53W6 Human Human Integrin alpha D beta 2 (ITGAD&ITGB2) Heterodimer Protein, His Tag&Tag Free
IT2-H53W6-sds
ACRO Quality

Part of Bioactivity data

IT2-H53W6-MALS-HPLC
Integrin alpha D beta 2 ELISA

Immobilized Human ITGAD&ITGB2 Heterodimer Protein, His Tag&Tag Free (Cat. No. IT2-H53W6) at 1 μg/mL (100 μL/well) can bind Human Integrin beta 2/CD18 Antibody with a linear range of 0.3-5 ng/mL (QC tested).

Protocol

Synonym Name

Integrin alpha D beta 2,ITGAD & ITGB2

Background

Integrin alpha-D/beta-2 is a receptor for ICAM3 and VCAM1. May play a role in the atherosclerotic process such as clearing lipoproteins from plaques and in phagocytosis of blood-borne pathogens, particulate matter, and senescent erythrocytes from the blood. Contributes to natural killer cell cytotoxicity. Involved in leukocyte adhesion and transmigration of leukocytes including T-cells and neutrophils. Triggers neutrophil transmigration during lung injury through PTK2B/PYK2-mediated activation (PubMed:18587400). Alpha D beta 2, selectively binds ICAM-3 and does not appear to bind ICAM-1. In addition, a soluble form of alpha D beta 2 binds VCAM-1 with greater efficiency relative to ICAM-3. The I domain of alpha D contains a binding site for VCAM-1 since recombinant alpha D I domain binds specifically to VCAM-1.

Clinical and Translational Updates

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